Please visit the National Library of Medicine National Center for Biotechnology Information Bibliography Page for Dr. Bohn for the most up-to-date list of her scientific publications. See older links below.
Ho, J. H., Stahl, E. L., Schmid, C. L., Scarry, S. M., Aube, J., Bohn, L. M. G protein signaling-biased agonism at the k-opioid receptor is mainted in striatal neurons. Science Signaling 2018 11 PMID:30087177
Kennedy, N. M., Schmid, C. L., Ross, N. C., Lovell, K. M., Yue, Z., Chen, Y. T., Cameron, M. D., Bohn, L. M., Bannister, T. D. Optimization of a series of mu opioid receptor (MOR) agonists with high G protein signaling bias. Journal of Medicinal Chemistry 2018 61:8895-8907 PMID:30199635
Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Pu M, Qu L, Korde A, Jiang S, Ho J-H, Han GW, Ding K, Li S, Liu H, Hanson MA, Zhao S*, Bohn LM*, Makriyannis A*, Stevens RC, Liu J-Z*. (2017) Crystal structures of agonist-bound human cannabinoid receptor CB1. Nature. 547 (7664): 468-471. PMID: 26878776
Bohn LM and Aubé J. (2017) Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor ACS Med. Chem. Lett. 8 (7): 694–700. PMID: 28740600
Mason JW, Schmid CL, Bohn LM, Roush WR. (2017) Stolonidiol: Synthesis, Target Identification, and Mechanism for Choline Acetyltransferase Activation. J Am Chem Soc. 139(16):5865-9. PMID: 28414442
Hua T, Vemuri K, Pu M, Qu L, Han GW, Wu Y, Zhao S, Shui W, Li S, Korde A, Laprairie RB, Stahl EL, Ho J-H, Zvonok N, Zhou H, Kufareva I, Wu B, Zhao Q, Hanson MA, Bohn LM*, Makriyannis A*, Stevens RC*, Liu J-Z.* (2016). Crystal Structure of the Human Cannabinoid Receptor CB1. Cell. 164: 750-762. PMID: 27768894. *corresponding.
Brust TF, Morgenweck J, Kim SA, Rose JH, Locke J, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, Aubé J, Jones SL, Martin TJ, Bohn LM. (2016) Biased agonists of the kappa opioid receptor suppress pain and itch while not causing sedation or dysphoria. Sci. Signal. 9: (456)ra117. PMID: 27899527
Rankovic Z, Brust TF, Bohn LM. (2016) Biased Agonism: An emerging paradigm in GPCR drug discovery. Bioorg. & Med. Chem. 26(2):241-50 PMID: 26707396
Morgenweck J, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM, (2015) Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus. Neuropharm. 99: 600-609 PMID: 26318102
Luttrell LM, Maudsley S, Bohn LM. (2015) Fulfilling the Promise of ‘Biased’ GPCR Agonism. Mol Pharmacol. 88(3):579-88 PMID: 26134495
Bohn LM, Lohse MJ, Nitabach M, Taghert PH, Smit MJ. (2015) Exploring the Biology of GPCRs from In Vitro to In Vivo. Mol Pharmacol. 88(3):534-5 Invited Commentary. PMID: 26162863. Special Edition of the Journal- Organizers’ commentary.
Stahl EL, Zhou L, Ehlert FJ, Bohn LM (2015) A novel method for analyzing extremely biased agonism at G protein-coupled receptors. Mol Pharm 87: 866-77 PMID: 25680753
Schmid CL, Streicher, JM, Meltzer HY, Bohn, LM. (2014). Clozapine acts as an agonist at serotonin 2A receptors to counter MK-801- induced behaviors through a βarrestin2-independent activation of Akt. Neuropsychopharmacology 39(8):1902-13 PMID: 24531562
Zhou L and Bohn LM. (2014) Functional Selectivity of GPCR Signaling in Animals. Current Opinion in Cell Biology (special edition, M von Zastrow and J Benovic, Editors), 27:102-8. PMID: 24680435
Zhou L, Lovell KM, Frankowski KJ, Slauson SR, Phillips AM, Streicher JM, Stahl EL, Schmid CL, Hodder P, Madoux F, Cameron MD, Prisinzano TE, Aube J, Bohn LM. (2013) Development of functionally selective, small molecule agonists at kappa opioid receptors. J Biol Chem. Nov 1. [Epub ahead of print] PMID:24187130
Schmid CL, Streicher JM, Groer CE, Munro TA, Zhou L, Bohn LM. (2013) Functional Selectivity of 6′-guanidinonaltrindole (6′-GNTI) at Kappa Opioid Receptors in Striatal Neurons. J Biol Chem. 288, 22387-22398. PMID: 23775075
Raehal KM, Schmid CL*, Groer CE*, Bohn LM. Functional selectivity at the mu opioid receptor: Implications for understanding opiate analgesia and tolerance. Pharmaco. Rev. 2011 Dec; 63(4):1001-19. doi: 10.1124/pr.111.004598. Epub 2011 Aug 26. Review.
PMID: 21873412 [PubMed – indexed for MEDLINE]
Tarselli MA, Raehal KM, Brasher AK, Streicher JM, Groer CE*, Cameron MD, Bohn LM^ and Micalizio GC^. Synthesis of conolidine, a Potent Non-opioid Analgesic for Tonic and Persistent Pain. Nature Chemistry, 2011 Jun;3(6)::449-453. doi: 10.1038/nchem.1050.
PMID: 21602859. [PubMed – indexed for MEDLINE]
Bohn, LM and Schmid, CL*. Serotonin Receptors Signaling and Regulation via Beta Arrestins. Critical Reviews biochem. and Mol. Biol. 2010 Dec;45(6):555-66. doi:10.3109/10409238.2010.516741. Epub 2010 Oct 7. Review.
PMID: 20925600 [PubMed – indexed for MEDLINE]
Schmid, CL and Bohn, LM. (2010) Serotonin, but not N-Methyltryptamines, activates the Serotonin 2A Receptor via a Beta Arrestin2/Src/Akt signaling complex in vivo. Journal of Neuroscience. 2010 Oct 6;30(40):13513-24. doi: 10.1523/JNEUROSCI.1665-10.2010.
PMID: 20926677 [PubMed – indexed for MEDLINE]
Bohn LM, McDonald PH. Seeking Ligand Bias: Assessing GPCR Coupling to Beta-Arrestins for Drug Discovery. Invited Review for Drug Discovery Today: Technologies, Theme issue: Mechanistic Pharmacology, new developments.2010Spring; 7(1):e37-e42.
PMID: 21218149 [PubMed]
Bohn, LM “Selectivity for G Protein or Arrestin-Mediated Signaling” in Functional Selectivity of GPCR Ligands. (Ed. K. Neve) Humana Press, Totowa, 2009, pp. 71-85.
Schmid CL, Raehal KM, Bohn LM. From the Cover: Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo. Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):1079-84. doi: 10.1073/pnas.0708862105. Epub 2008 Jan 14.
PMID: 18195357 [PubMed – indexed for MEDLINE]
Groer CE, Tidgewell K, Moyer RA, Harding WW, Rothman RB, Prisinzano TE, Bohn LM. An opioid agonist that does not induce mu-opioid receptor-β-arrestin interactions or receptor internalization. Mol Pharmacol. 2007 71(2):549-57.
Bohn LM, Raehal KM. Opioid receptor signaling: relevance for gastrointestinal therapy. Curr Opin Pharmacol. 2006 Dec;
6(6):559-63. Epub 2006 Aug 28. Review.
PMID:16935560 [PubMed – indexing for MEDLINE]
Raehal KM, Walker JK, Bohn LM. Morphine side effects in beta-arrestin 2 knockout mice. J Pharmacol Exp Ther. 2005 Sep;314(3):1195-201. Epub 2005 Mar 18.
PMID: 15917400 [PubMed – indexed for MEDLINE]
Bohn LM, Dykstra LA, Lefkowitz RJ, Caron MG, Barak LS. Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. Mol Pharmacol. 2004 66(1):106-12.
Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, Caron MG. ). Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature. 2000 408(6813):720-3.
Bohn LM, Lefkowitz RJ, Gainetdinov RR, Peppel K, Caron MG, Lin FT. (1999). Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science.286(5449):2495-8.